Under the Scope of the Alea Jacta EST project

Balmayor, E. R.; Feichtinger, G.; Azevedo, H. S.; van Griensven, M.; Reis, R. L. Starch-poly-e-caprolactone (SPCL) microparticles reduce the needed amount of BMP-2. Clinical Orthopaedics and Related Research (CORR) 2009. DOI: 10.1007/S11999-009-0954-Z

Balmayor, E. R.; Tuzlakoglu, K.; Marques, A. P.; Azevedo, H. S.; Reis, R. L. A Novel Enzymatically-Mediated Drug Delivery Carrier for Bone Tissue Engineering Applications: Combining Biodegradable Starch-based Microparticles and Differentiation Agents. Journal of Materials Science: Materials in Medicine 2007, 19(4): 1617- 1623.

Balmayor, E. R.; Tuzlakoglu, K.; Azevedo, H. S.; Reis, R. L. Preparation and characterization of novel starch-poly-e-caprolactone microparticles incorporating bioactive agents for drug delivery and tissue engineering applications. Acta Biomaterialia 2009, 5: 1035-1045.

Paula M. López-Pérez, Alexandra P. Marques, Ricardo M.P. da Silva, Iva Pashkuleva, and Rui L. Reis.Journal of Materials Chemistry, 2007,17,4064-4071

Martins A, Chung S, Pedro AJ, Sousa RA, Marques AP, Reis RL and Neves NM, 2008, Novel micro-nanofibrous multilayer scaffold for bone tissue engineering applications, TISSUE ENGINEERING PART A, 14:763-764 (2008)

Chung S, Martins A, Correlo VM, Oliveira JT, Marques AP, Neves NM, Mano JF, Sousa RA and Reis RL, 2008, Dependence of cell proliferation on the morphology of starch based scaffolds for tissue engineering, TISSUE ENGINEERING PART A, 14;718 (2008)

Martins A, Chung S, Pedro AJ, Sousa RA, Marques AP, Reis RL and Neves NM, 2008, Hierarchical starch- based fibrous scaffolds for bone tissue engineering applications, Journal of Tissue Engineering and Regenerative Medicine, 3;37-42 (2009)

Kirsebom, H., Aguilar, M. R., Roman, J. S., Fernandez, M., Prieto, M. A., Bondar, B. Scaffolds Based on Chitosan and Bioactive Molecules. Journal of Bioactive and Compatible Polymers, 2007, Vol 22, 621-636.

Alberto J. Campillo-Fernández, Ronald E. Unger, Kirsten Peters, Sven Halstenberg, Marina Santos, Manuel Salmerón Sánchez, Jose Maria Meseguer Dueñas, Manuel Monleón Pradas, Jose Luis Gómez Ribelles, C. James Kirkpatrick. "Analysis of the Biological Response of Endothelial and Fibroblast Cells Cultured on Synthetic Scaffolds with Various Hydrophilic/Hydrophobic Ratios: Influence of Fibronectin Adsorption and Conformation" Tissue Engineering Part A; doi:10.1089/ten.tea.2008.0146

Bondar B. Fuchs S, Motta A, Migliaresi C, Kirkpatrick CJ. Functionality of endothelial cells on silk fibroin nets: Comparative study of micro- and nanometric fibre size. Biomaterials, Vol. 29, Issue 5: 561-572, 2007 (doi:10.1016/j.biomaterials.2007.10.002)

Kirsebom H, Aguilar MR, San Roman J, Fernandez M, Prieto MA, and Bondar B. Macroporous Scaffolds Based on Chitosan and Bioactive Molecules. Journal of Bioactive and Compatible Polymers, Vol. 22, No. 6: 621-636, 2007

Cunha-Reis C, TuzlaKoglu K, Baas E, Yang Y, El Haj A and Reis RL. (2007) Influence of Porosity and Fibre Diameter on the Degradation of Chitosan Fibre-mesh Scaffolds and Cell Adhesion. Journal of Materials Science, 18, 195-200.

Cunha-Reis C, Bagnaninchi PO, El Haj AJ and Yang Y. (2007) Exploring fluorescence as a tool for real-time monitoring of scaffolds degradation. Tissue Engineering,13,1694-1694.

Yang Y, Bagnaninchi PO, Cunha-Reis C, Aydin HM, Piskin E, El Haj AJ (2007) Characterisation of scaffold architecture by optical coherence tomography, SPIE 8(16), 6439, (G)1-9.

A study on the influence of biocompatible composites with bioactive ligands towards their effect on cell adhesion and growth for the application in Bone Tissue Engineering. S. Röker, S. Böhm, S. Diederichs, F. Bode, A. Quade, V. Korzhikov, M. van Griensven, T. Tennikova, C. Kasper. Accepted for publication in Journal of Biomedical Material Research Part B.

Effects of repetitive and short time strain in human bone marrow stromal cells. S. Diederichs, F. Freiberger, M. van Griensven. Journal of Biomedical Material Research Part A. 2009 Mar 15;88(4):907-15 [Epub 2008 Apr 2].

Design and characterization of a rotating bed system bioreactor for tissue engineering applications. F. Anton, K. Suck, L. Behr, S. Diederichs, B. Hitzmann, M. van Griensven, C. Kasper, H. Hoffmeister, T. Scheper. Biotechnology Progress 2008 Jan-Feb;24(1):140-7. Epub 2008 Jan 17.

Under the Scope of the Alea Jacta EST project

Szymczyk W, Araujo JV, Martins A, Pinho ED, Neves NM, Marques AP and Reis RL, 2008, Co-culture of endothelial and smooth muscle cells for the development of blood vessel constructs, Tissue Engineering Part A, 14 (5) : 824-825

Ying Yang, Cassilda Cunha-Reis, Pierre O Bagnaninchi, Halil M Aydin, “Control and monitoring of scaffold architecture for tissue engineering” in Handbook of Fabrication and Processing of Biomaterials, pgs 69-94, Editors: Paul K Chu and Xuanyong Liu, CRC Press, in press

Bioreactor for Connective tissue engineering: Design and monitoring innovations

Mechanical strain using 2D and 3D bioreactors induces osteogenesis – implications for bone tissue engineering. M. van Griensven, S. Diederichs, S. Roeker, S. Boehm, A. Peterbauer, S. Wolbank, D. Riechers, F. Stahl, C. Kasper. Book chapter in Advances in Biochemical Engineering/Biotechnology. 2009;112:95-123 [Epub 2008 Sep 26].

Mechanical strain of bone marrow stromal cells induces proliferation and differentiation into osteoblast-like cells. M. van Griensven, S. Diederichs, C. Kasper. Book chapter in Topics in Tissue Engineering Volume 2, 2006.

Cultivating cells of different origin for 3d bone constructs considering physiological conditions. K. Suck, C. Kasper, C. Hildebrandt, S. Diederichs, M. Fischer, T. Scheper, M. van Griensven. Buchkapitel in Cell Technology for Cell Products, Verlag Springer Niederlande, 2007

Costa, PF , Martins A, Neves NM, Gomes ME and Reis RL, 2008, A novel bioreactor design for enhanced stem cells proliferation and differentiation in tissue engineered constructs, Tissue Engineering: Part A, 14 : 802

Costa, PF , Gardel LS, Rada T, Gomes ME and Reis RL, 2008, Stimulating adult stem cells from different origins for bone TERM approaches, Experimental Pathology and Health Sciences, 2(1) : 45

Alves da Silva ML, Martins A, Costa, PF, Correlo V M , Sol PC, Bhattacharya M, Rougier N., Reis RL and Neves NM, 2008, Cartilage Tissue Engineering Using a Flow Perfusion Bioreactor, Tissue Engineering: Part A, 14, 2008 : 708

Under the Scope of the Alea Jacta EST project

M. Cerqueira, A. Martins, B. Claes, A. P. Marques, N. Neves, R. L. Reis Influence of Patterned Electrospun Nanofiber Meshes on the Behaviour of Human Dermal Fibroblasts, InVENTS – 4th Marie Curie Cutting Edge Conference on Biocompatibility evaluation and biological behaviour of polymeric biomaterials, Alvor, Portugal, October, (2007)

Balmayor, E. R.; Tuzlakoglu, K.; Marques, A. P.; Azevedo, H. S.; Reis, R. L. "Enzymatic degradation behavior of starch-poly-caprolactone microparticles and the effect of their leachable products in contact human osteoblastic cell-line" on the 3rd Marie Curie Cutting-Edge InVENTS Conference (Biomineralisation of polymeric materials, bioactive biomaterials and biomimetic methodologies). 1st Summer School of TERMIS–EU, Funchal, Madeira, PORTUGAL (June 2007). ORAL PRESENTATION.

Balmayor, E. R.; Tuzlakoglu, K.; Azevedo, H. S.; Reis, R. L. “A Novel Enzymatically Controlled Drug Delivery Carrier, Combining Biodegradable Starch-based Microparticles and Differentiation Agents, for Bone Tissue Engineering Applications” on the European Society of Biomaterials: ESB 2007, UK (September 2007). ORAL PRESENTATION.

Balmayor, E. R.; Baran, E. T.; Azevedo, H. S.; Reis, R. L. “Starch-Chitosan microparticles as potential drug delivery carriers” on the 2nd Marie Curie Cutting Edge InVENTS Conference (Recent Advances on polymeric based systems for controlled delivery of bioactive agents: Applications in Tissue Engineering), Algarve, PORTUGAL (October 2006). ORAL PRESENTATION.

Balmayor, E. R.; Tuzlakoglu, K.; Azevedo, H. S.; Reis, R. L. “Preparation and characterization of novel starch-poly-caprolactone microparticles incorporating bioactive agents for drug delivery and tissue engineering applications” on the European Materials Research Society: E-MRS 2006 FALL MEETING (Symposium J Surface Functionalization and Activation of Biomaterials), Warsaw, POLAND (September 2006). ORAL PRESENTATION.

Balmayor, E. R.; Baran, E. T.; Marques, A. P.; Azevedo, H. S.; Reis, R. L. “Cytotoxicity evaluation of Starch-Chitosan hydrogels microspheres in contact with Page 10 of 14 SaOs-2 cultures” on the 4th Marie Curie Cutting-Edge InVENTS Conference. (Biocompatibility evaluation and biological behaviour of polymeric biomaterials), Alvor, Algarve, PORTUGAL (October 2007). ORAL PRESENTATION.

Balmayor, E. R.; Baran, E. T.; Azevedo, H. S.; Reis, R. L. "Highly biodegradable starch-conjugated chitosan microspheres as carriers for the controlled release of aminoglycosides antibiotic drugs" on the 8th World Biomaterials Congress 2008, Amsterdam, THE NETHERLANDS (28 May-1 June 2008). ORAL PRESENTATION.

Balmayor, E. R.; Bessa, P. C.; Tuzlakoglu, K.; Azevedo, H. S.; Casal, M.; Reis, R. L. “Novel biodegradable polymeric microparticles for the localized delivery of differentiation agents in bone tissue engineering applications” on the TERMIS-EU 2008 Annual meeting. Porto, PORTUGAL (June 2008). ORAL PRESENTATION.

Bessa, P. C.; Balmayor, E. R.; Cerqueira, M. T.; Rada, T.; Gomes, M. E.; Neves, N. M.; Azevedo, H. S.; Casal, M.; Reis, R. L. “Silk nanoparticles for delivery of human BMP-2 in bone regenerative medicine applications” on the TERMIS-EU 2008 Annual meeting. Porto, PORTUGAL (June 2008). ORAL PRESENTATION.

Balmayor, E. R.; Tuzlakoglu, K.; Azevedo, H. S.; Reis, R. L. “Starch-poly-caprolactone microparticles as delivery system of differentiation agents: preparation, characterization and in vitro release study”, International Workshop: Frontiers in Materials Research IV, Viña del Mar, CHILE (May 2008). POSTER.

Balmayor, E. R.; Rada, T.; Tuzlakoglu, K.; Gomes, M. E.; Azevedo, H. S.; Reis, R. L. “Development of novel polymer-ferromagnetic microparticles for cell isolation”, 8th World Biomaterials Congress 2008, Amsterdam, THE NETHERLANDS (May 2008). POSTER.

Lopez-Perez PM , Marques AP, Pashkuleva I and Reis RL, Plasma surface modification of chitosan membranes using different monomers aiming to improve the adhesion of Osteoblast-like cells, EMS-Fall Meeting 2006, Warsaw, Poland, September 2006(oral presentation)

Lopez-Perez PM , da Silva RMP , Pashkuleva I and Reis RL, Improved Adhesion Of Osteoblast-Like Cells On Chitosan Membranes Surface Modified Via Introduction Of Phosphonic Groups, TERMIS-EU, London, United Kingdom, September 2007(oral presentation)

Lopez-Perez PM , da Silva RMP , Pashkuleva I and Reis RL, Surface functionalization of chitosan membranes via phosphonic groups grafting: influence on Osteblast like-cells behaviour, 4th Marie Curie Cutting Edge Conference. Biocompatibility evaluation and biological behaviour of polymeric biomaterials, Alvor, Portugal, October 2007(oral presentation)

Chung S, Martins A, Correlo VM, Oliveira JT, Marques AP, Neves NM, Mano JF, Sousa RA, Reis RL “Dependence of Cell Proliferation on the Morphology of Starch Based Scaffolds for Tissue Engineering”, TERMIS- EU 08, Porto, Portugal, 2008

Martins A, Chung S, Pedro AJ, Sousa RA, Marques AP, Reis RL, Neves NM “Novel Micro-Nanofibrous Multilayer Scaffold for Bone Tissue Engineering Applications, TERMIS-EU 08, Porto, Portugal, 2008

Chung S, Correlo VM, Neves NM, Picciochi R, Mano JF, Sousa RA, Reis RA, “Dependence of Morphology on the Osteogenic Cell Proliferation of Starch Based Scaffolds”, Transactions of the 32nd Annual Meeting of the Society for Biomaterials 2007, Chicago, USA.

Chung S, Martins A, Marques AP, Neves NM, Sousa RA, Reis RA, “Effects of Scaffold Structure on Osteogenic Cell Behavior using Rapid Prototyping Technology”, Transactions of the 9th Annual Meeting of Korean Tissue Engineering and Regenerative Medicine Society 2007, Seoul, Korea.

Szymczyk W , Araujo JV, Martins A, Pinho ED, Neves NM, Marques AP and Reis RL, Evaluation of New Materials to Engineer Artificial Blood Vessels, 1st Marie Curie Cutting Edge Conference on “New developments on polymers for tissue engineering: replacement and regeneration”., Funchal, Madeira, Portugal, June 2006 (poster presentation)

Marques AP, Pirraco RP , Szymczyk W, Lopez-Perez PM, Pashkuleva I, Araujo JV, Martins A, Pinho ED, Neves NM and Reis RL, In vitro cell interactions: surface properties and co-culture models, Cell-Biomaterials Interactions Workshop, Prague, Czech Republic, October 2006 (oral presentation)

Szymczyk W , Martins A, Pinho ED, Araujo JV, Neves NM, Marques AP and Reis RL, Enhanced Behavior of Endothelial and Smooth Muscle Cells Co-Cultured on Polycaprolactone 2D bi-layer Structures, 2nd Marie Curie Cutting Edge InVENTS, Alvor, Portugal, October 2007 (oral presentation)

“BIOLOGICAL ACTIVITY IN HYDROGELS BASED ON HYALURONIC ACID AND A DERIVATIVE OF PYRROLIDONE” Magalhaes J, San Roman J, Crawford A, Hatton PV. 9th Annual White Rose Work in Progress Meeting, Leeds, UK (14th December 2007)

“SMART SYSTEMS BASED ON HYALURONIC ACID AND A POLYMERIC DERIVATIVE OF PYRROLIDONE” Magalhaes J, Elvira C, San Roman J. Expertissues Workshop: Cell-Biomaterial Interactions, Prague, Czech Republic (21st October 2006).

“BIOACTIVITY IN STIMULI RESPONSIVE SYSTEMS BASED ON HYALURONIC ACID AND A POLYMERIC DERIVATIVE OF PYRROLIDONE” Magalhaes J, Elvira C, San Roman J. 2nd Marie Curie Edge InVENTS Conference on Recent Advances on Polymeric Based Systems for Controlled Delivery of Bioactive Agents: Applications in Tissue Engineering, Alvor, Portugal (1st-5th October 2006).

“DEVELOPMENTS ON TISSUE ENGINEERING AND SELF-CURING SYSTEMS” Magalhaes J, Kirsebom H, Elvira C, San Roman J. Expertissues Workshop: “Cellular Aspects of Tissue Engineering”, Vienna, Austria (23th March 2006).

Growth of endothelial and fibroblast cells on acrylate scaffolds with varying hydrophilic/hydrophobic ratio. Campillo, A ;Fernández, RE. Unger, K. Perters, JL. Gómez Ribelles, JM. Meseguer Dueñas, M. Monleón Pradas, CJ. Kirkpatrick. Biomaterialen 7(3), 2006, 133, Essen (Germany), 2006

Bondar B, Fuchs S, Motta A, Migliaresi C, Kirkpatrick CJ. Adhesion Molecules And Actin Nucleators In Human Endothelial Cells Grown On Silk Fibroin Scaffolds. ESB’07. 09-13 September 2007. Brighton, UK

Fuchs S, Bondar B, Motta A, Migliaresi C, Kirkpatrick CJ. Focal contact formation and Integrin-β1 expression in endothelial cells on nanometric silk fibroin nets. FBPS, 24-27 June 2007. Ghent, Belgium

4th European Symposium on Biopolymers (ESBP2007), Turkey C. Cunha-Reis, A. J. El Haj, Y. Yang, “An On-line pH Sensor for Tissue Engineering”.

4th Marie Curie Cutting Edge Conference, Alvor, Portugal Cunha-Reis C, Bagnaninchi PO, El Haj AJ and Yang Y.”Towards the real time monitoring of scaffold degradation: a fluorescence based approach”.

TERMIS 2007 – Tissue Engineering and Regenerative Medicine International Society, London, UK. Cunha-Reis C, Bagnaninchi PO, El Haj AJ and Yang Y. “Exploring fluorescence as a tool for real-time monitoring of scaffolds degradation”.

ESB 2007 – Europeans Society of Biomaterials, Brighton, UK. Cunha-Reis C, Bagnaninchi PO, El Haj AJ and Yang Y. “Towards on-line monitoring the degradation of tissue engineering scaffolds”.

ESB 2006, European Conference On Biomaterials, Nantes, France. C.Cunha-Reis, K. TuzlaKoglu, Y. Yang, A. El Haj and R. L. Reis.“ Influence of Porosity/Fibre Diameter on the Degradation of Chitosan Fiber-mesh Scaffolds”.

4th European Symposium on Biopolymers (ESBP2007), Turkey. Cunha-Reis C, Bagnaninchi PO, El Haj AJ and Yang Y.”Towards The On-Line Monitoring of Scaffold Degradation : A Fluorescence Based Approach”

JANUARY 2007 SPIE Photonics West, San Jose, USA. Yang Y, Bagnaninchi PO, Cunha-Reis C, Aydin HM, Piskin E, El Haj AJ “Characterisation of scaffold architecture by optical coherence tomography”.

AUGUST 2006 5th International Mesostructured Materials Symposium Cassilda Cunha-Reis, Humphrey H.P. Yiu, Alicia El Haj and Ying Yang. "Preparation of fluorescent mesostructured particles by binding fluorescein molecules onto amine-SBA-15 silica”.

OCTOBER, 2005 2nd Alea Jacta EST / 2nd Expertissues Tutorial Course: Tissue Engineering of bone and cartilage: current trends and future perspectives, Antalya, Turkey Cassilda Reis, Kadriye TuzlaKoglu, Ying Yang, Alicia El Haj1 and Rui L. Reis, “Influence of porosity/fibre diameter on the degradation of chitosan fibre-mesh scaffolds – a preliminary study”.

Mechanical stimulation of adipose tissue derived mesenchymal stem cells. S. Diederichs, D. Riechers, B. Weyand, C. Kasper, T. Scheper, M. van Griensven.

Dynamic mesenchymal stem cell culturing for bone tissue engineering. S. Diederichs, D. Riechers, F. Sempf, C. Kasper, T. Scheper, M. van Griensven.

Investigation of the effect of mechanical strain on the osteogenic differentiation of mesenchymal stem cells. S. Diederichs, D. Riechers, F. Sempf, S. Kall, C. Kasper, M. van Griensven, T. Scheper.

Mechanical stimulation of adipose tissue derived mesenchymal stem cells for bone tissue engineering. S. Diederichs, S. Kall, C. Kasper, M. van Griensven, T. Scheper.

Adipose tissue derived stem cells for bone tissue engineering. S. Diederichs, C. Kasper, S. Kall, T. Scheper, M. van Griensven.

Mechanical straining of adipose tissue derived mesenchymal stem cells for application in bone tissue engineering. S. Diederichs, S. Kall, H. Hoffmeister, M. Wieland, C. Kasper, T. Scheper, M. van Griensven.

Osteogenic differentiation of mesenchymal stem cells using mechanical strain. S. Diederichs, K. Suck, C. Kasper, M. van Griensven.

Santos TC , Hoering B, Marques AP, Castro AG, Redl H, van Griensven M and Reis RL, In Vivo Assessment of the Inflammatory Response of Starch-based Scaffolds, 4th Marie Curie Cutting Edge Conference Biocompatibility evaluation and biological behaviour of polymeric biomaterials, 9-13 October 2007, Alvor, Algarve, Portugal, Alvor, Portugal, October 2007
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Santos TC , Tuzlakoglu K, Morton T, Lang K, Reise K, Marques AP, Castro AG, Redl H, Reis RL and van Griensven M, In vivo evaluation of the suitability of starch-based scaffolds for bone tissue engineering constructs using Adipose Derived Adult Stem Cells and transgenic mice, Society for Biomaterials 2007, Chicago, United States of America, April 2007
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Costa, PF, Martins A, Neves NM, Gomes ME and Reis RL, A novel bioreactor design for enhanced stem cells proliferation and differentiation in tissue engineered constructs, TERMIS-EU, Porto, Portugal, June 2008

Costa, PF, Gardel LS, Rada T, Gomes ME and Reis RL, Stimulating adult stem cells from different origins for bone TERM approaches, IX International Symposium on Experimental Techniques, Vila Real, Portugal, October 2008

Alves da Silva ML, Martins A, Costa, PF, Correlo V M , Sol PC, Bhattacharya M, Rougier N., Reis RL and Neves NM, Cartilage tissue engineering using a flow perfusion bioreactor, TERMIS-EU, Porto, Portugal, June 2008

Poster presentations: - IV Tissue Engineering Symposium, Tampere, March 2007 - British Society for Dental Research Meeting, Durham, April 2007 - UKSB, London, July 2007 - ECM VIII: Bone tissue engineering, Davos, June 2007 - IADR PEF Conference, Dublin, September 2006 - The Tissue & Cell Engineering Society Meeting, Sheffield, July 2006

Oral presentation at TERMIS EU meeting, London, September 2007 (‘Engineering of hypertrophic cartilage with and without poly(glycolic acid) scaffolds’)

Alves da Silva ML , Crawford A, Mundy JM, Martins A, Araujo JV, Hatton PV, Reis RL and Neves NM, Cartilage Tissue Engineering Using Polycaprolactone (PCL) and Starch Polycaprolactone (SPCL) Nanofiber Meshes, School of Engineering Day, University of Minho, Guimarães, Portugal, October 2007 (oral presentation)

Alves da Silva ML , Crawford A, Mundy JM, Correlo V M , Sol PC, Bhattacharya M, Hatton PV, Reis RL and Neves NM, Novel Chitosan/ Poly (Butylene Succinate) Scaffolds For Cartilage Tissue Engineering, TERMIS-EU, London, United Kingdom, September 2007 (oral presentation)

Alves da Silva ML , Crawford A, Mundy JM, Martins A, Araujo JV, Hatton PV, Reis RL and Neves NM, Polycaprolactone (PCL) and Starch Polycaprolactone (SPCL) Nanofiber Meshes: an Approach to Cartilage Tissue Engineering, TERMIS-NA, Toronto, Canada, June 2007 (oral presentation)

Alves da Silva ML , Costa-Pinto A. R., Crawford A, Mundy JM, Correlo V M , Sol PC, Bhattacharya M, Hatton PV, Reis RL and Neves NM, The Potential of Chitosan-Based Scaffolds for Bone and Cartilage Tissue Engineering, Genostem 3rd Workshop on Mesenchymal Stem Cells Enginnering for Conective Tissue Disorders, Barcelona, Spain, Barcelona, Spain, February 2007 (oral presentation)

Alves da Silva ML , Crawford A, Mundy JM, Martins A, Araujo JV, Hatton PV, Reis RL and Neves NM, Evaluation of the Potential of Polycaprolactone (PCL) and Starch Polycaprolactone (SPCL) Nanofiber Meshes for Cartilage Tissue Engineering Approaches, Society for Biomaterials Annual Meeting, Chicago, United States of America, April 2007 (poster presentation)

Alves da Silva ML , Crawford A, Mundy JM, Correlo V M , Sol PC, Bhattacharya M, Hatton PV, Reis RL and Neves NM, Evaluation of Bovine Articular Chondrocytes When Seeded into Chitosan/ Poly (Butilene Succinate) Scaffolds, Cartilage Biology and Pathology, Ventura, United States of America, March 2007 (poster presentation)

Alves da Silva ML , Crawford A, Mundy JM, Correlo V M , Sol PC, Bhattacharya M, Hatton PV, Reis RL and Neves NM, Evaluation of Extracelullar Marrix Formation on Chitosan-Based Scaffolds Using a Bovine Articular Chondrocytes Model for Articular Cartilage, Genostem 3rd Workshop on Mesenchymal Stem Cells Enginnering for Conective Tissue Disorders, Barcelona, Spain, February 2007 (poster presentation)

Under the Scope of the Alea Jacta EST project

JULY 2006 Tissue and Cell Engineering Society Annual Meeting, Sheffield University, UK C. Cunha-Reis, K. TuzlaKoglu, Y. Yang, A. El Haj and R. L. Reis “A New Method for Tailoring the Degradation Rate of Chitosan Fibre-mesh Scaffolds”.

C Cunha-Reis, K TuzlaKoglu, Y Yang, A El Haj, RL Reis, (2006), A new method for tailoring the degradation rate of chitosan fibre-mesh scaffolds, European Cells Materials Journal, 11 (Suppl. 3), pp35

Portuguese Patent Pending: Costa PF, Martins A, Gomes ME, Neves NM, Reis RL, Bioreactor multi-câmara com perfusão bidireccional para aplicação em estratégias de engenharia de tecidos.

1st Alea Jacta EST/ 1st Experttissue Tutorial Course on "Biomaterials and Tissue Engineering" July 11-17 Ischia Porto, NA, Italy.

2nd Alea Jacta EST / 2nd Expertissues Tutorial Course on "Tissue Engineering of Bone and Cartilage: Current Trends and Future Perpectives" 18/19th October 2005 Antalya, Turkey

3rd Alea Jacta EST / 3rd Expertissues Tutorial Course on “Drug Delivery, Targeting and Controlled Release of Growth Factors in Tissue Engineering”. 25/27th May 2006 Menorca, Spain

2nd Marie Curie Cutting Edge Conference (InVENTS) on "Recent Advances on polymeric based systems for controlled delivery of bioactive agents: Applications in Tissue Engineering". 1st/5th October 2006 Algarve, Portugal

3rd Marie Curie Cutting Edge Conference(InVENTS) / 1st Summer School of TERMIS – EU on "Biomineralisation of polymeric materials, bioactive biomaterials and biomimetic methodologies". 4/8th June 2007 Funchal, Madeira, Portugal

4th Marie Curie Cutting Edge Conference (InVENTS) on "Biocompatibility evaluation and biological behaviour of polymeric biomaterials". 9/13th October 2007 Alvor, Algarve, Portugal

5th Alea Jacta EST on “Biocompatibility evaluation and biological behavior of polymeric biomaterials”. 9/13th October 2007 Alvor, Algarve, Portugal

1st Alea Jacta EST

1st Alea Jacta EST/1st Expertissues Tutorial Course on "Biomaterials and Tissue Engineering" Ischia 16-17 July 2005

2nd Alea Jacta EST

2nd Alea Jacta EST / 2nd Expertissues Tutorial Course on "Tissue Engineering of Bone and Cartilage: Current Trends and Future Perpectives" Antalya 18/19th October 2005

3rd Alea Jacta EST

3rd Alea Jacta EST / 3rd Expertissues Tutorial Course on "Drug Delivery, Targeting and Controlled Release of Growth Factors in Tissue Engineering" Menorca 25-27th of May, 2006

5th Alea Jacta Est

5th Alea Jacta EST / 4th Marie Curie Cutting-Edge Conference on "Biocompatibility evaluation and biological behaviour of polymeric biomaterials" Algarve 9-13 October 2007

2nd Marie Curie Cutting Edge Conference (InVENTS) on "Recent Advances on polymeric based systems for controlled delivery of bioactive agents: Applications in Tissue Engineering". 1st-5th October 2006 Algarve, Portugal

Bioreactor Design Workshop for Skeletal tissue Engineering, 20-21 june 2007, University of Keele, Keele, UK

2nd Alea Jacta EST / 2nd Expertissues Tutorial Course on "Tissue Engineering of Bone and Cartilage: Current Trends and Future Perpectives" 18/19th October 2005 Antalya, Turkey

1st Annual International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 30 to 31 May, 2006

T. Rada, L.S. Gardel, L.A. Serra, M.E. Gomes, R.L. Reis."A novel cell-specific isolation method for Adipose Derived Stem Cell"

1st Marie Curie Cutting Edge Conference

1st Alea Jacta EST/ 1st Experttissue Tutorial Course on "Biomaterials and Tissue Engineering" Ischia Porto, NA, Italy, 16-17 July 2005

2nd Alea Jacta EST / 2nd Expertissues Tutorial Course on "Tissue Engineering of Bone and Cartilage: Current Trends and Future Perpectives" Antalya, Turkey, 18-19th October 2005

1st Annual International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Madeira, Portugal, 30-31 May, 2006

5th Alea Jacta EST / 4th Marie Curie Cutting-Edge Conference on "Biocompatibility evaluation and biological behaviour of polymeric biomaterials" Avor, Portugal 9-13 October 2007

3rd Alea Jacta Est & 3rd Expertissues Tutorial Course, Menorca, Spain (25-27th May 2006).

Expertissues Workshop: “Cellular Aspects of Tissue Engineering”, Vienna, Austria (23th March 2006).

2nd Alea Jacta Est & 2 nd Expertissues Tutorial Course, Antalya, Turkey (18-19th October 2005).

1st Expertissues Tutorial Course, Ischia, Italy (16-17th July 2005)

2 nd Expertissues Tutorial Course, Antalya, Turkey (18-19th October 2005)

3rd Alea Jacta Est & 3rd Expertissues Tutorial Course, Menorca, Spain (25-27th May 2006).

2nd Marie Curie Edge InVENTS Conference on Recent Advances on Polymeric Based Systems for Controlled Delivery of Bioactive Agents: Applications in Tissue Engineering, Alvor, Portugal (1st-5th October 2006)

Expertissues Training Course: Cell-Biomaterial Interfaces- From Theory to Practice, Prague, Czech Republic (17th-20th October 2006).

Expertissues Workshop: Cell-Biomaterial Interactions, Prague, Czech Republic (21st October 2006)

1st Alea Jacta EST / 1st Expertissues Tutorial Course

"Biomaterials and Tissue Engineering". 16-17 July 2005. Ischia, Italy

2nd Alea Jacta EST / 2nd Expertissues Tutorial Course

“Tissue Engineering of Bone and Cartilage: Current Trends and Future Perpectives”. 18-19 October 2005. Antalya, Turkey. Poster “Human formins and other cytoskeleton related proteins as markers for endothelial cells biocompatibility assessment” (Bondar B, Fuchs S, Kirkpatrick CJ).

EXPERTISSUES Workshop and 18 Months Meeting of the NoE EXPERTISSUES

"Cellular Aspects of Tissue Engineering", 23-26 March 2006. Vienna, Austria. Poster presentation: "Cellular adhesion and cytoskeleton-related proteins as markers for endothelial cells biocompatibility assessment" (Bondar' B, Fuchs S, Kirkpatrick CJ).

3rd Alea Jacta EST / 2nd Expertissues Tutorial Course

Drug Delivery, Targeting and Controlled Release of Growth Factors in Tissue Engineering 25-27th of May, 2006. Menorca, Spain

Bioreactor Design workshop

Bioreactor Design for skeletal tissue engineering training course. 20-2st of June, 2007. Keele University, Keele, England

OCTOBER 2007 4th Marie Curie Cutting Edge Conference: Biocompatibility Evaluation And Biological Behaviour Of Polymeric Biomaterials, Alvor, Algarve, Portugal.

JUNE 2006 Bioreactor Design and Stem Cell Processing Workshop, Buxton, UK

OCTOBER, 2005 2nd Alea Jacta EST / 2nd Expertissues Tutorial Course: Tissue Engineering Of Bone And Cartilage: Current Trends And Future Perspectives, Antalya, Turkey

JULY, 2005 12th CIRMIB biomaterials school / 1st expertissues summer school: From Biomedical Devices To Molecular Recognition And Tissue Engineered Products, Ischia, Italy 1st alea jacta est / 1st expertissues tutorial course: Biomaterials & Tissue Engineering, Ischia, Italy

Expertissue Workshop, Keele University, Jun 2007

Bioreactor and stem cell designing process

1st Alea Jacta EST/ 1st Experttissue Tutorial

1st Alea Jacta EST/ 1st Experttissue Tutorial Course on "Biomaterials and Tissue Engineering" Ischia Porto, NA, Italy

2nd Alea Jacta EST / 2nd Expertissues Tutorial

2nd Alea Jacta EST / 2nd Expertissues Tutorial Course on "Tissue Engineering of Bone and Cartilage: Current Trends and Future Perpectives" 18/19th October 2005 Antalya, Turkey

1st Alea Jacta EST / 1st Expertissues Tutorial Course "Biomaterials and Tissue Engineering". 16-17 July 2005. Ischia, Italy

4th Alea Jacta EST / 4th Expertissues Tutorial Course on “Bioreactor design and stem cell processing workshop”, June 2006. Keele University, England

EXPERTISSUES Workshop and 18 Months Meeting of the NoE EXPERTISSUES "Cellular Aspects of Tissue Engineering", 23-26 March 2006. Vienna, Austria.

3rd Alea Jacta EST / 3rd Expertissues Tutorial Course on “Drug delivery, targeting and control release of growth factors in tissue engineering”, May 2006

2nd Alea Jacta EST / 2nd Expertissues Tutorial Course “Tissue Engineering of Bone and Cartilage: Current Trends and Future Perpectives”. 18-19 October 2005. Antalya, Turkey.

Bioreactor Design and Stem Cell Processing Workshop – Buxton, England, June 2006